コラーゲン加水分解物の褥瘡治癒促進効果

—無作為割付けプラセボ対照化二重盲検試験—

Collagen Hydrolysate Enhanced Pressure Ulcer Healing 

in a Randomized Double-blind Placebo-controlled Clinical Study

杉原 富人¹⁾     井上 直樹^1） 小泉 聖子¹⁾    Sriraam VT*²⁾

*医師

1）新田ゼラチン株式会社

2）Aurous Health Care Research and Development Private Ltd.

Fumihito Sugihara , Naoki Inoue , and Seiko Koizumi : Nitta Gelatin Inc . Peptide Division ; VT Srraam : Aurous Health Care Research and Development Private Ltd .

ABSTRACT

Effect of a specific collagen hydrolysate (CH) , which contains bioactive dipeptides , on healing of pressure ulcer was investigated in a randomized , placebo-controlled , double-blind trial . All subjects with Stage II or ll pressure ulcer were treated with standard therapy , and we compared CH intake and placebo intake group. End point was a comparison between groups of levels of Pressure Ulcer Scale for Healing (PUSH) score , Pressure Score Status Tool (PSST)core and decubitus area score 16 weeks after ingestion. The levels of PUSH score and PSS score in the CH group decreased significantly compared to the placebo group (P<0.01) . The level of decubitus area score in the CH group was also reduced significantly (P<0.05) than the level in the placebo group . Though there was no significant difference in blood albumin level of the subjects between the two groups , an intra-group significant difference in the level was observed in the CH group . This study demonstrated that the CH intake has a pressure ulcer healing effect added to the standard therapy.