Clinical Effects of Ingesting Collagen Hydrolysate

on Facial Skin Properties

—A Randomized, Placebo-controlled, Double-blind Trial—

Fumihito Sugihara^1）    Naoki Inoue¹⁾    Xuemin Wang²⁾

1)peptide Division , Nitta Gelatin Inc

2)shanghai Skin Disease Hospital

ABSTRACT

Objectives：The objective of this research was to investigate the effectiveness of daily ingestion of a specific collagen hydrolysate (CH), which contains prolylhydroxyproline (Pro-hyp) and hydroxyprolylglycine (Hyp-Gly) , on facial skin properties.

Methods：In this randomized, placebo-controlled , double-blind trial, 56 women aged 30-55 years were randomized to receive 2.5 g of CH or 5 g of placebo once daily for 8 weeks . with 28 subjects assigned to each group . The hydration , elasticity and roughness properties of facial skin were measured at week 0 ( baseline ), week 4 and week 8.

Results：Levels of skin hydration , elasticity and roughness in subjects who received CH significantly improved between baseline and weeks 4 and 8 , while there was no significant improvement in subjects who received placebo . Moreover , the levels of skin elasticity , roughness and the net change of skin hydration improved significantly in the CH group compared to the placebo group by both weeks 4 and 8.

Conclusion：The present results suggest that daily ingestion of 2.5 g of CH improves facial skin hydration, elasticity and roughness. (Jpn Pharmacol Ther 2015; 43 : 67-70 )